Noven is a fully-integrated specialty pharmaceutical company with industry-leading transdermal expertise


Estradiol Transdermal System

In November 2018, Noven launched Estradiol Transdermal System, the authorized generic to Minivelle® (estradiol transdermal system) in the U.S. This state-of-the-art patch, developed and manufactured by Noven, is indicated for the treatment of moderate to severe vasomotor symptoms due to menopause and for the prevention of post-menopausal osteoporosis. It is available in five dosage strengths (0.025, 0.0375, 0.05, 0.075 and 0.10 mg/day). The 0.025 strength is indicated only for the prevention of post-menopausal osteoporosis. Noven markets and sells Estradiol Transdermal System through Grove Pharmaceuticals, Noven’s authorized generic division. 

Click here to find the authorized generic at a pharmacy near you.

For more information, please call 844-884-6796.


Estradiol Transdermal System is a prescription medicine patch that contains estradiol (an estrogen hormone). Estradiol Transdermal System is used to reduce moderate to severe hot flashes due to menopause and to help prevent postmenopausal osteoporosis (thin weak bones). The 0.025 mg/day dose is only approved for the prevention of postmenopausal osteoporosis.

If you use Estradiol Transdermal System only to prevent osteoporosis from menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you.


What is the most important information I should know about Estradiol Transdermal System (an estrogen hormone)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Estradiol Transdermal System as vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

  • Do not use estrogen-alone or estrogen with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).

  • Using estrogen-alone may increase your chances of getting strokes or blood clots, while using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

  • Using estrogen-alone or estrogen with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.

  • You and your healthcare provider should talk regularly about whether you still need treatment with Estradiol Transdermal System.

Estradiol Transdermal System should not be used if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack, currently have or have had blood clots, currently have or have had liver problems, have been diagnosed with a bleeding disorder, are allergic to Estradiol Transdermal System or any of its ingredients, or think you may be pregnant.

Before you take Estradiol Transdermal System, tell your healthcare provider if you have unusual vaginal bleeding, have any other medical conditions, are going to have surgery or will be on bed rest, are breast feeding, and about all of the medicines you take.

The most common side effects that may occur with Estradiol Transdermal System are headache, breast tenderness, back and limb pain, common cold, upset stomach, nausea, inflammation of the sinuses and irregular vaginal bleeding or spotting.

Estradiol Transdermal System should be used at the lowest effective dose and for the shortest duration consistent with your treatment goals and risks.

These are not all the possible effects of Estradiol Transdermal System. Please read the Patient Information section within the full Prescribing Information before taking Estradiol Transdermal System. For more information ask your healthcare provider or pharmacist for advice about side effects.

Click here for the full Prescribing Information, including Boxed WARNING.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

For information call 1-800-455-8070. Please see our Privacy Policy for more information.

Dot MatrixTM is a trademark of Noven Pharmaceuticals, Inc.

MINIVELLE® and the Minivelle Logo are trademarks of Noven Therapeutics, LLC.

Vivelle-Dot® is a registered trademark of Novartis AG.

For patient, physician and pharmacist inquiries regarding Estradiol Transdermal System, please contact:
Tel: 844-884-6796.