Noven is a fully-integrated specialty pharmaceutical company with industry-leading transdermal expertise


CombiPatch® (estradiol/norethindrone acetate transdermal system)

First U.S. Combination Patch

CombiPatch® (estradiol/norethindrone acetate transdermal system), developed and manufactured by Noven, was the first combination (two-drug) patch approved in the U.S.  CombiPatch is a combination transdermal hormone therapy patch containing both estrogen and progestin designed specifically for postmenopausal women who still have their uterus to treat symptoms of moderate to severe hot flashes, and vaginal dryness associated with menopause.  It is available in two dosage options (0.05/0.25 mg/day and 0.05/0.14 mg/day). Noven markets and sells CombiPatch through the Women’s Health unit of its specialty pharmaceuticals subsidiary, Noven Therapeutics, LLC.

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CombiPatch® (estradiol/norethindrone acetate transdermal system) is a prescription medicine used to treat moderate to severe hot flashes associated with menopause; treat moderate to severe dryness, itching and burning in or around the vagina associated with menopause; and treat certain conditions in which a young woman’s ovaries do not produce enough estrogens naturally. If you use CombiPatch only to treat your dryness, itching and burning in or around the vagina, talk with your healthcare professional about whether a topical vaginal product would be better for you.


Do not use estrogens and progestins to prevent heart disease, heart attacks, strokes or dementia (decline in memory and thinking skills). Using estrogens with progestins may increase your chances of getting heart attacks, strokes, blood clots, and breast cancer and may increase your risk of dementia.

You and your healthcare professional should talk regularly about whether you still need treatment with CombiPatch® and whether you are taking the lowest dose that works for you.

Do not use CombiPatch® if you have had your uterus removed (hysterectomy). CombiPatch® should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, blood clots, or liver problems; had a stroke or heart attack; have been diagnosed with a bleeding disorder; are allergic to CombiPatch® or any of its ingredients; or think you may be, or know that you are, pregnant.

Before you take CombiPatch®, tell your healthcare provider if you have unusual vaginal bleeding, have any other medical conditions, are going to have surgery or will be on bed rest, are breast feeding, and about all of the medicines you take.

The most common side effects that may occur with CombiPatch® are breast pain, vaginal bleeding, and headache. These are not all the possible side effects of CombiPatch®.

Click here for the Full Prescribing Information, including Boxed WARNING for CombiPatch®.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

CombiPatch® and the graphic design are trademarks of Noven Pharmaceuticals, Inc. All other registered trademarks are the property of their respective owners.

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For patient, physician and pharmacist inquiries regarding CombiPatch®, please contact:
Tel: 800-455-8070

More Information

CombiPatch® Patient, Physician
and Pharmacist Inquiries:

Tel: 800-455-8070